ADME |
- Absorption: Caco2_Wang, HIA_Hou, Pgp_Broccatelli, Bioavailability_Ma, Lipophilicity_AstraZeneca, Solubility_AqSolDB, HydrationFreeEnergy_FreeSolv
- Distribution: BBB_Martins, PPBR_AZ, VDss_Lombardo
- Metabolism: CYP2C19_Veith, CYP2D6_Veith, CYP3A4_Veith, CYP_1A2_Veith, CYP2C9_Veith, CYP2C9_Substrate_CarbonMangels, CYP2D6_Substrate_CarbonMangels, CYP3A4_Substrate_CarbonMangels
- Execretion: Half_Life_Obach, Clearance_Hepatocyte_AZ, Clearance_Microsome_AZ
|
Tox |
hERG, AMES, DILI, Skin Reaction, LD50_Zhu, Carcinogens_Lagunin, ToxCast, Tox21, ClinTox |
HTS |
HIV, SARSCoV2_3CLPro_Diamond, SARSCoV2_Vitro_Touret, Orexin1 Receptor, M1 Muscarinic Receptor Agonists, M1 Muscarinic Receptor Antagonists, Potassium Ion Channel Kir2.1, KCNQ2 Potassium Channel, Cav3 T-type Calcium Channels, Choline Transporter, Serine/Threonine Kinase 33, Tyrosyl-DNA Phosphodiesterase |
QM |
QM7b, QM8, QM9 |
Yields |
Buchwald-Hartwig, USPTO |
Epitope |
IEDB_Jespersen, PDB_Jespersen |
Develop |
TAP, SAbDab_Chen |
CRISPROutcome |
Leenay |