Biomedical Knowledge Graph

HetioNet

Description: Hetionet is an integrative network of biomedical knowledge assembled from 29 different databases of genes, compounds, diseases, and more. The network combines over 50 years of biomedical information into a single resource.

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References:

[1] Himmelstein, Daniel Scott, et al. “Systematic integration of biomedical knowledge prioritizes drugs for repurposing.” Elife 6 (2017): e26726.

[2] Himmelstein, Daniel S., and Sergio E. Baranzini. “Heterogeneous network edge prediction: a data integration approach to prioritize disease-associated genes.” PLoS Comput Biol 11.7 (2015): e1004259.

Drug Repurposing Library

Broad Repurposing Hub

Description: The Drug Repurposing Hub is a curated and annotated collection of FDA-approved drugs, clinical trial drugs, and pre-clinical tool compounds with a companion information resource. Order library plates to screen yourself or collaborate with the Broad Institute’s Center for the Development of Therapeutics to see if an existing drug may work against your novel target, model system, or indication. While the collection will undoubtedly reveal new uses for developed drugs, its true power is unlocked when applied to discover new biological insights and disease mechanisms.

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References:

[1] Corsello, Steven M., et al. “The Drug Repurposing Hub: a next-generation drug library and information resource.” Nature medicine 23.4 (2017): 405-408.